Review



tlr4 specific inhibitor tak242  (TargetMol)


Bioz Verified Symbol TargetMol is a verified supplier
Bioz Manufacturer Symbol TargetMol manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 94
      Buy from Supplier

    Structured Review

    TargetMol tlr4 specific inhibitor tak242
    Tlr4 Specific Inhibitor Tak242, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 11 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/tlr4+specific+inhibitor+tak242/Resatorvid/pm39550424-180-39-43
    Average 94 stars, based on 11 article reviews
    tlr4 specific inhibitor tak242 - by Bioz Stars, 2026-10
    94/100 stars

    Images

    Related Articles

    Saline:

    Article Title: A novel role of peroxiredoxin 2 in diabetic kidney disease progression by activating the classically activated macrophages.
    Article Snippet: .. After full adherence and stretch, cells were treated with phosphate buffered saline (PBS) in the negative control group (NC group), with 5 μg/mL recombinant PRDX2 (HZbscience, HZF757Mu01) in the PRDX2 group and pre-treatment with or without 1 μM of TLR4 specific inhibitor TAK242 (Targetmol, TQ0181) for 1 h. After 12 or 24 h, cells were collected for WB analysis to detect the protein expression level of M1 and M2 polarization related protein. ..

    Article Title: A novel role of peroxiredoxin 2 in diabetic kidney disease progression by activating the classically activated macrophages
    Article Snippet: .. After full adherence and stretch, cells were treated with phosphate buffered saline (PBS) in the negative control group (NC group), with 5 μg/mL recombinant PRDX2 (HZbscience, HZF757Mu01) in the PRDX2 group and pre-treatment with or without 1 μM of TLR4 specific inhibitor TAK242 (Targetmol, TQ0181) for 1 h. After 12 or 24 h, cells were collected for WB analysis to detect the protein expression level of M1 and M2 polarization related protein. ..

    Negative Control:

    Article Title: A novel role of peroxiredoxin 2 in diabetic kidney disease progression by activating the classically activated macrophages.
    Article Snippet: .. After full adherence and stretch, cells were treated with phosphate buffered saline (PBS) in the negative control group (NC group), with 5 μg/mL recombinant PRDX2 (HZbscience, HZF757Mu01) in the PRDX2 group and pre-treatment with or without 1 μM of TLR4 specific inhibitor TAK242 (Targetmol, TQ0181) for 1 h. After 12 or 24 h, cells were collected for WB analysis to detect the protein expression level of M1 and M2 polarization related protein. ..

    Article Title: A novel role of peroxiredoxin 2 in diabetic kidney disease progression by activating the classically activated macrophages
    Article Snippet: .. After full adherence and stretch, cells were treated with phosphate buffered saline (PBS) in the negative control group (NC group), with 5 μg/mL recombinant PRDX2 (HZbscience, HZF757Mu01) in the PRDX2 group and pre-treatment with or without 1 μM of TLR4 specific inhibitor TAK242 (Targetmol, TQ0181) for 1 h. After 12 or 24 h, cells were collected for WB analysis to detect the protein expression level of M1 and M2 polarization related protein. ..

    Recombinant:

    Article Title: A novel role of peroxiredoxin 2 in diabetic kidney disease progression by activating the classically activated macrophages.
    Article Snippet: .. After full adherence and stretch, cells were treated with phosphate buffered saline (PBS) in the negative control group (NC group), with 5 μg/mL recombinant PRDX2 (HZbscience, HZF757Mu01) in the PRDX2 group and pre-treatment with or without 1 μM of TLR4 specific inhibitor TAK242 (Targetmol, TQ0181) for 1 h. After 12 or 24 h, cells were collected for WB analysis to detect the protein expression level of M1 and M2 polarization related protein. ..

    Article Title: A novel role of peroxiredoxin 2 in diabetic kidney disease progression by activating the classically activated macrophages
    Article Snippet: .. After full adherence and stretch, cells were treated with phosphate buffered saline (PBS) in the negative control group (NC group), with 5 μg/mL recombinant PRDX2 (HZbscience, HZF757Mu01) in the PRDX2 group and pre-treatment with or without 1 μM of TLR4 specific inhibitor TAK242 (Targetmol, TQ0181) for 1 h. After 12 or 24 h, cells were collected for WB analysis to detect the protein expression level of M1 and M2 polarization related protein. ..

    Western Blot:

    Article Title: A novel role of peroxiredoxin 2 in diabetic kidney disease progression by activating the classically activated macrophages.
    Article Snippet: .. After full adherence and stretch, cells were treated with phosphate buffered saline (PBS) in the negative control group (NC group), with 5 μg/mL recombinant PRDX2 (HZbscience, HZF757Mu01) in the PRDX2 group and pre-treatment with or without 1 μM of TLR4 specific inhibitor TAK242 (Targetmol, TQ0181) for 1 h. After 12 or 24 h, cells were collected for WB analysis to detect the protein expression level of M1 and M2 polarization related protein. ..

    Article Title: A novel role of peroxiredoxin 2 in diabetic kidney disease progression by activating the classically activated macrophages
    Article Snippet: .. After full adherence and stretch, cells were treated with phosphate buffered saline (PBS) in the negative control group (NC group), with 5 μg/mL recombinant PRDX2 (HZbscience, HZF757Mu01) in the PRDX2 group and pre-treatment with or without 1 μM of TLR4 specific inhibitor TAK242 (Targetmol, TQ0181) for 1 h. After 12 or 24 h, cells were collected for WB analysis to detect the protein expression level of M1 and M2 polarization related protein. ..

    Expressing:

    Article Title: A novel role of peroxiredoxin 2 in diabetic kidney disease progression by activating the classically activated macrophages.
    Article Snippet: .. After full adherence and stretch, cells were treated with phosphate buffered saline (PBS) in the negative control group (NC group), with 5 μg/mL recombinant PRDX2 (HZbscience, HZF757Mu01) in the PRDX2 group and pre-treatment with or without 1 μM of TLR4 specific inhibitor TAK242 (Targetmol, TQ0181) for 1 h. After 12 or 24 h, cells were collected for WB analysis to detect the protein expression level of M1 and M2 polarization related protein. ..

    Article Title: A novel role of peroxiredoxin 2 in diabetic kidney disease progression by activating the classically activated macrophages
    Article Snippet: .. After full adherence and stretch, cells were treated with phosphate buffered saline (PBS) in the negative control group (NC group), with 5 μg/mL recombinant PRDX2 (HZbscience, HZF757Mu01) in the PRDX2 group and pre-treatment with or without 1 μM of TLR4 specific inhibitor TAK242 (Targetmol, TQ0181) for 1 h. After 12 or 24 h, cells were collected for WB analysis to detect the protein expression level of M1 and M2 polarization related protein. ..



    Similar Products

    tlr4 specific inhibitor tak242  (TargetMol)
    94
    TargetMol tlr4 specific inhibitor tak242
    Tlr4 Specific Inhibitor Tak242, supplied by TargetMol, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/tlr4+specific+inhibitor+tak242/Resatorvid/pm39550424-180-39-43
    Average 94 stars, based on 1 article reviews
    tlr4 specific inhibitor tak242 - by Bioz Stars, 2026-10
    94/100 stars
    		  Buy from Supplier
    specific tlr4 inhibitor tak242  (MedChemExpress)
    98
    MedChemExpress specific tlr4 inhibitor tak242
    Specific Tlr4 Inhibitor Tak242, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/tlr4+specific+inhibitor+tak242/Resatorvid/pm36586798-39-9-13
    Average 98 stars, based on 1 article reviews
    specific tlr4 inhibitor tak242 - by Bioz Stars, 2026-10
    98/100 stars
    		  Buy from Supplier
    tlr4-specific inhibitor tak242  (Millipore)
    90
    Millipore tlr4-specific inhibitor tak242
    APM inhibits LPS-induced CD11b and TNFα expression by inhibiting TLR4 in BV and rat primary microglial cells. Cells were treated with APM for 1 h followed by LPS for 12 h. CD11b and TNFα expression were significantly inhibited in LPS-stimulated BV2 ( A ) and rat primary microglial cells ( B ) by TLR4 inhibitor, <t>TAK242.</t> Cells were treated with APM for 1 h followed by LPS for 6 h. APM significantly reduced LPS-induced TLR4 expression in BV2 ( C ) and rat primary microglial cells ( D ). Immunofluorescence double staining for TLR4 (green) and TNFα (red) localization ( E ) in BV2 microglial cells. Cell were counterstained with DAPI (blue). Magnification 400×. Enlarge figure of scale bars: 5 μm. βActin was used to confirm equal sample loading. CD11b, TNFα and TLR4 followed by densitometric analysis. The data are representative of three independent experiments and quantified as mean values ± SEM. Tukey’s multiple comparison test, * p < 0.05, ** p < 0.01, *** p < 0.001 compared to normal control.
    Tlr4 Specific Inhibitor Tak242, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/tlr4+specific+inhibitor+tak242/tlr4+inhibitor+tak+242/pmc07352249-140-14-19
    Average 90 stars, based on 1 article reviews
    tlr4-specific inhibitor tak242 - by Bioz Stars, 2026-10
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    APM inhibits LPS-induced CD11b and TNFα expression by inhibiting TLR4 in BV and rat primary microglial cells. Cells were treated with APM for 1 h followed by LPS for 12 h. CD11b and TNFα expression were significantly inhibited in LPS-stimulated BV2 ( A ) and rat primary microglial cells ( B ) by TLR4 inhibitor, TAK242. Cells were treated with APM for 1 h followed by LPS for 6 h. APM significantly reduced LPS-induced TLR4 expression in BV2 ( C ) and rat primary microglial cells ( D ). Immunofluorescence double staining for TLR4 (green) and TNFα (red) localization ( E ) in BV2 microglial cells. Cell were counterstained with DAPI (blue). Magnification 400×. Enlarge figure of scale bars: 5 μm. βActin was used to confirm equal sample loading. CD11b, TNFα and TLR4 followed by densitometric analysis. The data are representative of three independent experiments and quantified as mean values ± SEM. Tukey’s multiple comparison test, * p < 0.05, ** p < 0.01, *** p < 0.001 compared to normal control.

    Journal: International Journal of Molecular Sciences

    Article Title: Apamin Suppresses LPS-Induced Neuroinflammatory Responses by Regulating SK Channels and TLR4-Mediated Signaling Pathways

    doi: 10.3390/ijms21124319

    Figure Lengend Snippet: APM inhibits LPS-induced CD11b and TNFα expression by inhibiting TLR4 in BV and rat primary microglial cells. Cells were treated with APM for 1 h followed by LPS for 12 h. CD11b and TNFα expression were significantly inhibited in LPS-stimulated BV2 ( A ) and rat primary microglial cells ( B ) by TLR4 inhibitor, TAK242. Cells were treated with APM for 1 h followed by LPS for 6 h. APM significantly reduced LPS-induced TLR4 expression in BV2 ( C ) and rat primary microglial cells ( D ). Immunofluorescence double staining for TLR4 (green) and TNFα (red) localization ( E ) in BV2 microglial cells. Cell were counterstained with DAPI (blue). Magnification 400×. Enlarge figure of scale bars: 5 μm. βActin was used to confirm equal sample loading. CD11b, TNFα and TLR4 followed by densitometric analysis. The data are representative of three independent experiments and quantified as mean values ± SEM. Tukey’s multiple comparison test, * p < 0.05, ** p < 0.01, *** p < 0.001 compared to normal control.

    Article Snippet: Cells were pretreated with various inhibitors such as TLR4-specific inhibitor (Millipore, Bedford, MA, USA): TAK242 (500 nM), NF-κB-specific inhibitor (Sigma-Aldrich): Bay11-7085 (10 μM), STAT3-specific inhibitor (Sigma-Aldrich): S3I-201 (10 μM) and ERK1/2-specific inhibitor (Cell signaling, Danvers, MA, USA): PD98059 (10 μM).

    Techniques: Expressing, Immunofluorescence, Double Staining, Comparison, Control